Influence of Magnesium Oxide on Antipyretic Action and Toxicity of Acetylsalicylic Acid in Rabbits

Conclusions

1. Quantities of acetylsalicylic acid and magnesium oxide, which have no antipyretic action when administered separately, have a marked antipyretic action when administered together. 2. The toxicity of acetylsalicylic acid is not influenced by the simultaneous administration of magnesium oxide. 3. The toxicity of a mixture of 50% magnesium oxide and 50% of acetylsalicylic acid is half as great as the toxicity of the amount of acetylsalicylic acid which is required to produce the same therapeutic effect.