Effect of Cinchophen on the Liver and Other Tissues of the Dog. ∗

During a study of peptic ulcers produced by the administration of cinchophen we had the opportunity of studying the effects of large amounts of cinchophen on the liver and other organs of the dog. In view of the divergence of opinions regarding the effects of cinchophen on the livers of experimental animals, it seems advisable to record our observations on this subject.

Specimens of liver were obtained from 131 dogs which were normal in every case before the experiment was begun. They were given the routine kennel care and were fed a balanced diet of a calculated weighed amount sufficient for their caloric requirements. Cinchophen was for the most part administered orally; in a few cases it was given rectally, parenterally, or through intestinal fistulas.

Thirty-one dogs, whose average weight was 17 kg., were daily given 2 gm. of cinchophen well mixed with their food for a period varying from 3 to 60 days. The average length of time over which administration of the drug to this group was continued was 27 days; the average total dose of cinchophen was 50 gm.

Fifty-four dogs were given 2 gm. of cinchophen daily, with an occasional rest day, for an average of 30 days but in a few cases over a period of time as long as 114 days. To this group the amount of cinchophen administered varied from 36 to 228 gm. during the course of treatment.

Thirteen dogs, whose average weight was 13 kg., were given varying doses of cinchophen by routes other than by mouth, the usual dose exceeding 1 gm. daily. To members of this group an average of 21 gm. of the drug was given in an average of 13 days.