IV. p-Bromophenylmercapturic Acid and Ethereal Sulfates Synthesis in Dogs Maintained on Diets of Varying Sulfur Content

Summary

1. Dogs were fed diets of varying sulfur content and 1.0 gm. doses of bromobenzene were fed on 4 consecutive days on each of the diets. The synthesis of p-brornophenylrnercapturic acid and ethereal sulfates on these diets was estimated. 2. The extent of the synthesis of the mercapturic acid and of the ethereal sulfates is apparently a function of the nutritive state of the animal: when the animal was deprived of dietary sulfur, a decrease in the output of mercapturic acid and an increase in the output of ethereal sulfates was noted. 3. The results offer further support to the previous suggestion that the dietary sulfur is not the immediate source which is used for the detoxication of blromobenzene in dogs.