Isolation and Properties of the Factor Responsible for Increased Capillary Permeability in Inflammation. ∗

Conclusions

For the sake of convenience the name Leukotaxin is tentatively proposed for this active crystalline nitrogenous substance which is evidently released by injured tissue and is readily recovered in inflammatory exudates. “Leukotaxine”per se appears to be capable of rapidly initiating the usual sequences of the inflammatory reaction first by inducinw a prompt increase in capillary permeability and secondly by causing an extremely rapid aggregation and migration of leucocytes through the endothelial wall.