The Localized Sanarelli-Shwartzman Phenomenon in the Rabbit Kidney

Summary and Conclusions

1. The production of a localized Sanarelli-Shwartzman phenomenon in the rabbit kidney was attempted, both by local vascular and direct parenchymal injection of B. coli filtrate. In neither instance was it possible to restrict the reaction to the kidney. 2. The results suggest that sufficient filtrate entered the systemic circulation from the preparatory injection to prepare the entire animal for a generalized reaction, and make it doubtful that the production of a localized renal phenomenon is possible. 3. The late lesions of the generalized phenomenon are described. These seem to indicate the relative insignificance of the renal lesions in surviving animals as compared to those of the liver and the myocardium.