Sulfanilamide and Diaminodiphenylsulfone and Their Diacetyl Derivatives in the Treatment of Experimental Intradermal Streptococcus Infections of Rabbits

Summary

(1)Sulfanilamide by oral administration to rabbits showed curative effects upon local intradermal streptococcus lesions but did not result in complete bactericidal effects in the dosage employed. (2) The acetyl derivative of sulfanilamide was practically without curative effects. (3) 4,4′-diaminodiphenylsulfone was more curative than sulfanilamide and produced complete bactericidal effects in the larger does. (4) The diacetyl derivative of 4,4′-diaminodiphenylsulfone as without curative effects in the the same dosage as sulfanilamide but produced some curative effects in higher dosages. (5) The results with sulfanilamide, 4,4′-diaminodiphenylsulfone and its diacetyl derivative by oral administration to rabbits with experimental intradermal streptococcus infections have not been as good as reported in the treatment of experimental streptococcus infections of mice by parenteral administration; the differences in results may be due to the difference in the species of animals employed and partly to the routes of administration.