Therapeutic Effect of 4,4′-Diamino-Diphenyl-Sulfone,Corresponding Sulfide and Acetyl Derivatives in Streptococcic Infection

Conclusions

1. 4,4′-diamino-diphenyl-sulfone is about 3 times as toxic for the rabbit as is sulfanilamide; 4,4′-diamino-diphenyl-sulfide is 5 times as toxic. 2. The corresponding diacetyl derivatives of sulfone and sulfide are less toxic than sulfanilamide. 3. The minimum therapeutic doses given daily for 5 consecutive days are as follows: for sulfanilamide, 0.005 g, for 4,4′-diamino-diphenyl-sulfone, 0.0005 g, for diamino-diphenyl-sulfide, 0.003 g, for di (acetyl-amino)- diphenyl-sulfone, 0.001 g, and for di(acetyl-amino)-diphenyl-sulfide, 0.002 g. 4. In mice infected with beta-Streptococcus hemolyticus, 4,4′-diamino-diphenyl-sulf one is therapeutically active in a dose 10 times smaller than that required by sulfanilamide. This indicates a considerably higher therapeutic efficacy of the sulfone over sulfanilamide.