Abstract
Summary and Conclusion
The maximum non-lethal dose and universal lethal dose of solustibosan and ureastibamine in normal Chinese hamsters were determined and their values were compared with those neostibosan. In terms of their antimony contents hamsters tolerated much more antimony in the form of solustibosan than in the form of either neostibosan or ureastibamine. Evidently solustibosan is least, while ureastibamine is most toxic among the 3 antimony compounds for normal hamsters.
In the infected hamsters much more antimony in the form of solustibosan than that in the form of either neostibosan or ureastibamine was required to bring abut a cure. It is obvious that ureastibamine is the most and solustibosan the least potent drug in the treatment of infected hamsters. The mortality rate during the course of treatment was highest with ureastibamine and lowest with solustibosan, but the differences are not statistically significant.
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