Some Effects of Menopause Urine Extract on Sexual Organs of Immature Female Cats

Summary and Conclusions

Five of 8 immature female cats, 6 to 13 weeks of age, responded to menopause urine extract with follicle stimulation although lutein tissue predominated in one case. Ovarian weight increased as much as four-fold as compared to 4 immature controls. In general, the right ovary responded to a greater extent than did the left ovary. In 2 cases, the left ovary had not responded, whereas the right ovary was stimulated. A second series of injections failed to initiate a response in one cat which had been negative to the first test and the left ovary of another cat failed to respond to further injections although the right ovary had responded to the initial treatment. This lack of uniformity in response appeared even between members of the same litter. It would appear that neither the general condition nor the age of the animal was the factor determining the response, but rather some property peculiar to the individual ovary.