Abstract
Disturbances of carbohydrate metabolism including hypersensi-tivity to insulin have been described in animals following the production of hypothalamic lesions (Ingram and Barris; 1 Cleveland and Davis; 2 Ingram and Winter; 3 Brobeck 4 ), and it has been suggested that such disturbances may be due to interruption of nervous connections with the anterior lobe of the hypophysis (Davis, Cleveland and Ingram: 5 Houssay 6 ).
The possibility that the fibers of the hypophyseal stalk are concerned with this function has been disproved by administering insulin intravenously to monkeys (Macaca mulatta) which had fully recovered from section of the infundibular stalk just proximal to the dorsal surface of the gland.
The details of operation and exact locations of the lesions have been reported (Magoun and Ranson 7 ). The procedure for the tests was the same as that already reported for cats (Brobeck 4 ) except that the dosage of insulin used for the monkeys was 0.1 unit per 0.2 kg body weight, and blood samples were taken before insulin injection and afterwards at the end of each hour for 3 hours. Blood sugars were estimated by the Randies and Grigg 8 modification of the Folin-Wu method.
The results of tests on 3 normal monkeys are compared with tests on 4 operated animals in Graphs I and IL The responses of the 2 groups of animals were quite similar, and the operated animals appeared no more sensitive to insulin than normal. Recovery from hypoglycemia did not take place as rapidly in the monkeys as it does in normal cats (Brobeck 4 ), but there was no difference in the amount of recovery shown by normal and operated monkeys, and no external hypoglycemic symptoms were observed.
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