Vaginal Cycle of Microtus guentheri and Its Response to Estrogenic and Gonadotropic Hormones

Summary

In Microtus guentheri no vaginal cycle with a cornification stage occurs as in white mice and rats. Injections of large closes of estrogenic hormone, however, induce cornification. Gonado-tropic hormone derived from different sources produces different reactions, that from pregnancy urine shows no effect, that from mare's blood serum induces follicle maturation without luteinization even in large doses, while that from animal hypophysis produces follicular maturation and corpus luteum formation. The Microtus guentheri may therefore be readily used as a test animal in differentiating the various types of gonadotropic hormone, especially as to their source of origin.