Lessened Effectiveness of Bacteriostatic Agents vs. Tuberculous Infection in Rabbits with Impaired Functional Efficiency

Summary

Sulfanilamide and P-caproylaminobenzenesulfon-hydroxamide, producing 20 and 60% inhibition of growth, respectively, in broth cultures of the avian tubercle bacillus, exert a comparable degree of restriction on the rate of increase in size of the local lesion produced by subcutaneous injection of this organism, in rabbits with warming times less than 40, but not in rabbits with warming times appreciably longer than 40.