Protecting Action of Chemicals Related to Procaine on Ventricular Fibrillation During Cyclopropane Anesthesia

Conclusions

The administration of p-amino benzoic acid, the calcium double salt of benzyl succinic and p-amino benzoic acids, or sodium p-amino benzoate prior to a test dose of epinephrine during cyclopropane anesthesia reduced the incidence of ventricular fibrillation. The intracardiac injection of procaine at the time when ventricular fibrillation developed effected a return to normal in a number of cases. Ventricular fibrillation was not ameliorated by the intracardiac injection of the other three p-amino benzoic acid derivatives.

The authors wish to express their appreciation for the helpful suggestions of Dr. Arthur C. DeGraff.