Abstract
Conclusions
It has been shown that the acute toxicity of sodium sulfamethylthiazole in rats, as measured by intraperitoneal injection, is almost twice as high as that of sodium sulfathiazole, which in turn is slightly greater than the toxicity of sodium sulfapyridine.
The pH and buffer capacities of solutions of the sodium salts, and differences in solubility of the free compounds as factors influencing the toxicity, are discussed.
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