Experimental Streptococcal Infections in Animals for Therapeutic Investigations. I. Virulence-tests

Conclusion

Hamsters and white mice are suitable animals for testing virulence of Streptococcus hemolyticus when injected by the intracerebral route. It requires only 40-400 organisms to kill the animal when given intracerebrally, whereas it requires 400,000 when given interpleurally and 4,000.000-11,500,000 when given intraabdominally and intravenously.