Absorption and Excretion of Sulfadiazine. ∗

Summary

1. Sulfadiazine was rapidly absorbed into the blood stream and comparatively high levels of total drug were reached.

2. The proportion of conjugated sulfadiazine in the blood was small.

3. The blood level falls rather slowly after the drug is discontinued.

4. Most of the drug is excreted by the kidney. 5. In 4 patients given 2 g of sulfadiazine and in 8 patients given a total of from 7 to 16 g the only toxic reaction noted was a morbilliform rash in one case in the latter group.