Influence of Protamine Zinc Insulin upon Appetite During Anorexia of Vitamin B 1 Deficiency

Summary

The administration of protamine zinc insulin which leads to a marked hyperalimentation in normal rats is without effect upon the depressed appetite of rats suffering from vitamin B₁ deficiency. These deficient rats succumb in hypoglycemia without an increase in their food intake when the insulin is administered. When thiamin chloride is given to B₁-deficient rats their appetite responds not only to the vitamin therapy but to protamine zinc insulin as do normal animals.