Choleretic Action and Excretion of Ginchophen in Rabbit Bile

Summary and Conclusions

The chloretic action of various doses of cinchophen was studied in a relatively. large number of anesthetized rabbits. Cinchophen in doses ranging from 10 to 50 mg per kilo had no appreciable effect on the volume output of bile. It was also found that, on the average, only 3 mg of cinchophen per rabbit was recovered in the bile over a period of 2 hours. Since it was found that the absence of cinchophen choleresis in the rabbit was not due to an acute intoxication of the liver, because after cinchophen sodium dehydrocholate caused a brisk choleresis, it is tentatively concluded that cinchophen does not cause choleresis in the rabbit because it is not excreted in the bile.