Continued Administration of Sulfathiazole on Renal and Hepatic Function in the Dog

Conclusions

1. The continued administration of sulfathiazole to dogs over a period of 10 days in doses of 250 mg per kg per day produces slight impairment of renal function as evidenced by elevation of the blood urea nitrogen level, and diminution in the urea clearance and P.S.P. excretion. 2. This impairment of function is reversible and normal values are reëstablished within 48 hours after the withdrawal of the drug. 3. Doses of this order have no demonstrable effect on O₂ capacity, O₂ and CO₂ content. 4. Doses of this order have no demonstrable effect on liver function as indicated by the rate of excretion of bromsulphonphthalein.