Comparative Anticonvulsant Activity of 1-Diethylacetyl-5,5-Cyclopentamethylene Biuret,Sodium Diphenyl Hydantoinate and Sodium Pentobarbital in Mice. ∗

Summary

The anticonvulsant activity of 1-diethylacetyl-5, 5-cyclopentamethylene biuret was compared in inbred mice with that of sodium dilantin and sodium pentobarbital. The biuret and pentobarbital protected the majority of animals given cocaine but they did not prevent death. All cocaine-treated mice given dilantin died from convulsions. Against surely fatal doses of picrotoxin and strychnine the dialkylacetyl biuret was effective in 19 of 20 animals. Dilantin had no effect against picrotoxin but saved half of the strychnine-treated animals. Sodium pentobarbital prevented convulsions in mice given picrotoxin and saved 5 of 10. It was anticonvulsant in the majority of strychnine poisoned mice but did not prevent death.