Abstract
Summary
p-Nitrobenzenesulfonamide is rapidly reduced by rat liver suspensions. After oral administration p-nitrobenzenesulfonamide is rapidly reduced by rats; a high percentage of the dose is excreted in the reduced form, and the extent of conjugation of the reduced form is large. A small amount of the drug is excreted in a state of oxidation above that of the amine. Azobenzene-4,4′-disulfonamide administered subcutaneously to rats is excreted slowly, reduced to only a small extent and conjugated to only a low degree.
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