Abstract
Summary
The response of monkeys to primary intranasal inoculation with Streptococcus hemolyticus, Group C, was characterized chiefly by a prompt but fleeting polymorphonuclear leucocytosis with occasional minor recurrent granulocytic elevations, followed by a transitory anemia. The opsonocytophagic index, antistreptolysin and precipitin titers were not significantly affected. Clinical manifestations of disease were mild but definite, and it is concluded that the cellular reaction, aided, if at all, only in slight degree by humoral factors, was the principal demonstrable defensive mechanism which these monkeys mobilized in successfully opposing the initial invasion by streptococci via the respiratory tract.
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