Toxicity of 3,3-Methylenebis (4-hydroxycoumarin)

Summary

(1) The median lethal doses of Dicumarol have been determined intravenously or by mouth in mice, rats, and guinea pigs. (2) Death uniformly occurs in rabbits with intravenous injection of daily doses of 1-2 mg per kg; in dogs with oral administration of daily doses of 5-50 mg per kg; and in mice and rats with the feeding of 0.01-1% Dicumarol in food. The majority of rabbits can tolerate daily doses of 0.1-0.5 mg per kg by vein for 6 weeks, and a few mice and rats can survive 30 days on a diet containing 0.005% Dicumarol. (3) Most animals dying from Dicumarol develop hemorrhage into various tissues and organs, and pulmonary edema. Central necrosis of the liver has been observed in about one-half of the rats examined, and occasionally in rabbits, mice, and dogs.