Abstract
Summary
A standardized procedure for carrying out the toxoplasma neutralization test in rabbits was described. The sera of 59 of 151 selected individuals were positive. A very high incidence of positive tests was found in infants and children presenting psy-chomotor disturbances with or without hydro-cephalus or microcephaly only when these were associated with cerebral calcification or chorioretinitis in the macular region or both. The congenital character of the disease was confirmed by the regular presence of these antibodies in the mothers of the affected children. Chorioretinitis affecting predominantly the macular region, and resembling that seen in cases of proved congenital toxoplasmosis, but occurring in otherwise apparently normal children and adults was associated with neutralizing antibodies for toxoplasma in 9 of 10 individuals. Certain other morbid conditions associated with toxoplasma neutralizing antibodies were also briefly described.
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