Prolonged Adrenalin Hypertension and Subsequent Circulatory Failure. ∗

Conclusion

In about 50% of our experiments prolonged administration of adrenalin (.00694 to .0398 mg kilo/min.) caused 2-7 hr after cessation of infusion either dynamic evidence of irreversibility or postmortem changes in the upper intestine which resembled those of hemorrhagic hypotension. Adrenalin constriction can lead to shock, but does not unfailingly do so. Our experiments have no bearing on the problems, whether equally intensive generalized constriction occurs in other types of clinical or experimental shock or whether lesser degrees of vasoconstriction can cause similar consequences.