Hypertensin,Hydroxytyramine and Action of Renal Hypertensor Extracts

Summary

The vasoconstrictor action of hypertensin and of the vasoconstrictor principle formed anaerobically by the action of renal tissue on dopa have been the subjects of study. It was shown that hypertensin has no vasoconstrictor effect in the Loewen-Trendelenburg test at a level producing a marked hypertension effect in the cat. Renal hypertensinase behaves similarly both aerobically and anaerobically, and its activity is not affected by cyanide or octyl alcohol, from which it is concluded that there is a cleancut difference between this enzyme, amino oxidase and tyrosinase. These findings support the finding that hypertensinase has the characteristics of a polypeptidase (Croxatto and Croxatto 6 ).