Mechanism of Sulfonamide Action. III. Biological Action of Substituted p -Aminobenzoic Acids. ∗

Summary

The biological action of substituted p-aminobenzoic acids studied in this series of experiments is summarized in Table V.

Substitutions on the ring of p-aminobenzoic acid resulted in compounds which were either inactive or had varying degrees of sulfonamide or antisulfonamide action. Although the compounds with sulfonamide action are relatively non-toxic, their value in systemic chemotherapy has not been demonstrated.