Dicumarol (3,3′-Methylene-Bis-(4-Hydroxy-Coumarin)) in Rats with Impaired Liver or Kidney Function.

Summary

Experiments in rats are described in which the effect of gradually increasing liver damage upon the action of Dicumarol was studied. Injections of carbon tetrachloride which do not significantly influence the prothrombin level greatly sensitize rats to Dicumarol. Bilateral nephrectomy results in a prolonged and increased effect of this drug. These findings indicate the necessity of care in the administration of this drug to patients having even a mild degree of liver damage or suffering from impairment of the kidney function.