Endosteal Bone Deposition in Femurs of Vitamin D-Deficient Mice Treated with Estrogen.

Summary

Obliteration of the marrow cavity of the femur by endosteal bone and some resorption of pubic bone was observed in C3H mice fed commercial stock diets and treated with estrogen. Comparable treatment of CHI mice did not cause obliteration of the marrow cavity of the femur although some resorption of pubic bone was noted.

C3H mice treated with estrogen and fed a vitamin D-deficient diet supplemented with viosterol showed the typical changes in the femur. This result was also obtained in animals fed the same diet unsupplemented with vitamin D. Under the conditions of these experiments dietary vitamin D did not play a major role in the mechanism of endosteal bone deposition in the femurs of mice treated with estrogen.