Abstract
Summary
Glycogen determinations were made on the heart, liver, and skeletal muscle of rats with alloxan-produced diabetes mellitus and on the same tissues of untreated controls. The alloxan-treated animals showed a statistically significant increase in glycogen content of heart muscle and a statistically significant decrease in liver and skeletal muscle glycogen.
Rats which developed diabetes mellitus had a high blood sugar and high blood ketones at the time of autopsy.
On histological examination of the tissues, the islet cells of alloxan-treated rats which developed diabetes showed a marked reduction in cytoplasm, pycnosis and decrease in size of the nuclei with resultant collapse of islet structure. Almost all kidney and liver sections showed some degenerative changes.
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