Phthalates and Vitamin K.

Summary

When tested by oral administration to baby chicks, no vitamin K activity was observed for dipropyl, di-isopropyl, or dibutyl phthalate at a level of 10 mg per chick, or for diethyl phthalate in doses as high as 100 mg per chick. These results differ from those reported in some rat experiments, in which diethyl phthalate was considered active. When tested by a single dose method in depleted chicks, diethyl phthalate did not show anti-vitamin K activity.