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A Characterization of a Urinary Fraction Capable of Producing Myeloid Metaplasia in Guinea Pigs *

Experimental Biology and Medicine

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Research article

First published online January, 1945

A Characterization of a Urinary Fraction Capable of Producing Myeloid Metaplasia in Guinea Pigs *

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Volume 58, Issue 1

https://doi.org/10.3181/00379727-58-14817

Abstract

Heinle, Wearn, Weir, and Rose¹ reported myeloid hyperplasia and metaplasia in guinea pigs following the injection of extracts and adsorbates of human urine. The majority of potent preparations had been obtained from patients with chronic myeloid leukemia.

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