Ulcer Production in Intestines of Dogs by Various Enzymes Under Hydrostatic Pressure

Summary

1. The proteolytic enzymes, rennin, trypsin, and erepsin, under hydrostatic pressure of 90 cm H₂O produced necrosis of the intestines of dogs, rennin being the most active of the three. 2. The average time required to produce a perforation with N/10 HCl alone was about 50% more than with rennin in N/10 HCl. 3. Neither steapsin nor amylopsin caused necrosis under the above condition.