Abstract
Summary
Several agents were tested for protective action against carbon tetrachloride injury of the liver in rats. Marked protection was obtained with sodium thioglycollate, appreciable protection with glutathione, moderate protection with sodium thiomalate, and slight protection with cystein—all sulphydryl compounds. Sodium glycollate and sodium malate afforded protection comparable to their sulphydryl homologues. Methionine, and choline plus cystine did not afford protection. Other non-sulphydryl compounds, i.e., sodium thiosulphate, aspartic acid, glutamic acid, choline, and sodium acetate afforded no protection.
A protective action against carbon tetrachloride injury of the liver in rats is not as closely related to the presence of -SH in the test agent as previously was observed for the protective action of certain compounds against hepatic injury by chloroform in the dog.
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