Blood Concentration of P-chloro-xylenol in Man Following Parenteral,Percutaneous and Rectal Application. ∗

Summary

The presence of free p-chloroxylenol (CX) in the blood shows that this substance is resorbed after parenteral, oral, rectal, as well as percutaneous application. Only 1% of the amount of CX applied was detected in the blood. In percutaneous treatment, the skin acts as a depot from which CX is slowly resorbed into the blood, and as a result a prolonged circulation of CX in active form in the blood is obtained. The prolonged circulation of CX in the blood in active form following different routes of administration renders its chemotherapeutic efficacy in man comprehensible.