Abstract
The lipotrophic activity of choline in experimental fatty cirrhosis of the liver, has been demonstrated by several groups of investigators. 1 , 2 , 3 The possibility of similar action on other types of cholesterol deposition in other tissue, particularly in atheromatous lesions in the aorta, has suggested itself. The naturally occurring human-like subintimal aortic atheromatosis as reported by Dauber 4a was chemically studied in 3-year-old certified 260 to 320 egg R.P.O. sired hens and the average level of certain chemical components established.4b The effect of choline on this pathological chemistry presented itself as an important problem.
Steiner 5 first and then Bauman and Rusch 6 and about simultaneously Himsworth 7 reported that they had not been able to demonstrate any action of choline on the high blood, aortic or liver content of cholesterol in cholesterol-fed rabbits. Andrews and Broun 8 concluded that cholin protected against atherosclerosis and Huber, Broun, and Casey 9 using lipocaic re ported the prevention of atherosclerosis in cholesterol-fed rabbits. Steiner 10 intimated that choline may hasten reabsorption of atheromas.
The data from the original control series A of 26 3-year-old hens are set down for comparison.
A summer-autumn (S&A) and a winter spring (W&S) choline fed series, each of 26 3-year-old hens individually caged and fed all that they would eat of a high fat and protein laying mash (Purina) and given, in addition, 0.5 g choline chloride daily. With the summer and autumn (S&A) choline series
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