Abstract
Summary
Fifteen weeks after the forelimbs of young rats were denervated, it was found: (1) The growth in length of the radii was affected earlier and to a greater degree than that of the humerus. (2) The reduction of growth in diameter of the humeri was greater than the reduction of growth in length. (3) Growth in diameter of the bones was reduced but not prevented. (4) The quantity of bone and of bone salt was reduced by about 25%. (5) The humeri, but not the radii, of both the normal and paralyzed limbs of rats 132 days of age, had practically ceased to grow in length.
It is concluded that paralysis of a limb interferes more with appositional growth of bones than with epiphyseal growth and that bone growth is not prevented in a denervated limb.
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