Abstract
Summary
The LDloo of histamine was first determined in a control group of guinea pigs. It was found that approximately 5 times this amount was required to kill all animals previously treated with 3 mg/kg of Benadryl, while 35 times the lethal dose of histamine was necessary to produce 100% mortality in animals receiving 3 mg/kg of Pyribenzamine. No apparent difference was discernible between the 2 drugs in preventing anaphylaxis in passively sensitized guinea pigs. One mg/kg of either compound gave significant protection against a shocking dose of antigen, while 3.0 mg/kg prevented fatal anaphylaxis in all animals tested.
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