Allergic Sensitization to penicillin

Conclusions

1. Mild preexisting sensitivity to pure crystalline sodium penicillin G, injected intradermally, was demonstrable occasionally in guinea pigs and rabbits.

2. Typical general sensitivity could not be demonstrated with pure penicillin G applied to guinea pigs by local or parenteral routes.

3. Local sensitization of the Arthus type phenomenon was produced consistently by repeated injections into rabbits of pure sodium penicillin G, or commercial calcium penicillin. These reactions were comparable to those produced by similar injections of horse serum, but somewhat less intense.

4. Similar local sensitization was observed in a patient injected with commercial penicillin in oil and beeswax. 5. Accordingly, the purest obtainable crystalline penicillin can act as a sensitizing agent with manifestations like those of native protein, and the skin is the outstanding organ for the seat of the allergic reaction.