Abstract
Summary
The administration of 0.1% thiouracil in the feed for 24 days to young female rats reduced the lactogenic hormone content of the pituitary below that in normal rats. The proven ability of estrogen to increase the lactogen content of the pituitary remained unimpaired in rats which were given the estrogen together with thiouracil for 21 days. However, when rats received thiouracil alone for a 2-week preliminary period, the subsequent administration of estrogen plus thiouracil for 10 days failed to maintain even the normal level of lactogenic hormone.
The pituitary and thyroid weights of the thiouracil as well as thiouracil plus estrogentreated rats were increased above the norrnal controls. The thyroid hypertrophy in the rats which received estrogen and thiouracil for 10 days following a preliminary treatment of thiouracil alone for 2 weeks was less than in the rats which received only thiouracil for the same period.
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