Effects of Radiotoxic Dosages of I 131 upon Thyroid and Contiguous Tissues in Mice. ∗

Summary

Dosages of I¹³¹ from 3 to 50 millicuries per kilogram were given to young mice on a normal diet. Higher dosages produced complete thyroidal destruction within a few days. Lower dosages permitted survival of some thyroidal epithelium in the iathmus and cranial apex of the thyroid for as long as 120 days after injection, but resulted in loss of the parathyroids. Lesions were noted in the tracheal epithelium with all does ages, md in the recurrent laryngeal nerve with higher dosages.