Abstract
Conclusions
1. Diabetes was produced by the injection of alloxan in 15 of 19 hypophysectomized rats. 2. The diabetes so produced tended to be either transitory or fluctuating in severity and it is suggested that this phenomenon represents the “Houssay effect” seen in tlepancreatized hypophysectomized dogs. 3. Extensive loss of beta cells in the islets of Langerhans was noted in all animals in which satisfactory histological preparations were obtained. The presence of hypophysis is therefore not necessary for the production of what appears to be the essential lesion in alloxan diabetes.
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