Effect of Lipotropic Agents in a Diet Containing Pure Amino Acids in Place of Protein

Summary

Rats fed an alipotropic diet in which a mixture of amino acids replaced protein developed fatty livers in spite of low food intake and emaciation. Methionine in adequate dosage exerted a lipotropic effect although there was still 10% of fat in the liver when the methionine constituted 2.4% of the diet. When 25 mg of choline chloride per day were fed the livers were essentially normal.