Abstract
Summary
1. Rats fed a 16% casein, 51% fat diet for 29 weeks all developed markedly fatty livers. Nearly all of the animals showed a diffuse, progressive hepatic fibrosis.
2. The fatty change and fibrosis were completely prevented by supplementing the high-fat diet with choline, or with crude liver extract.
3. The lipotropic effect of the liver extract is not due to an increase in protein intake resulting from a stimulation of appetite, and is not due to the small amount of choline present in the liver extract.
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