Effect of Rutin on Dicoumarolism. ∗

Conclusions

Under the experimental conditions employed, rutin does not antagonize dicoumarolism in rats. Presumably the defect in the vessel walls or their supporting structures which leads to hemorrhage in dicoumnrolism differs from that leading to the various hemorrhagic conditions which rutin and related “vitamin P”-like substances purportedly benefit. These facts, however, need not necessarily preclude the simultaneous use of dicoumarol and “vitamin P” for their separate effects, as illustrated by the report of MacLean and Brabel 17 on the favorable effects of rutin and dicoumarol in various retinal vascular disorders.