On the behavior of autodermic and isodermic skin grafts in cancer

I have observed in cases having growing cancers that isodermic grafts of skin from husband and from son caused a marked local reaction, characterized by excessive exudation, edema, redness and finally by the complete break-down of the grafts, while autodermic grafting later was entirely successful.

Tests in other cases were made by applying a single isograft alongside of autografts. In the cases thus far known to have at the time growing cancer, the isografts did not live. In other cases, we have not yet the final data. Histologic studies showed degeneration of the deeper cellular elements of the isografts. Nine cases were thus observed.