Glutamic Acid and Vomiting in Dogs: Its Administration into the Portal System and Extremity Veins. *

Summary and Conclusions

A method is presented by which the spleen may be readily transplanted subcutaneously in dogs and used for intraportal infusions.

Dogs could tolerate more glutamic acid solution without vomiting when it was given either intrasplenically or directly into the portal vein by using the angiostomy technic, as compared to the peripheral venous administration.

The increased tolerance to glutamic acid solution when given intraportally is attributed to the direct passage of these amino acids to the liver where they may be removed from the circulation.