Effect of Elevated Body Temperatures on Cryptococcosis in Mice

Summary

1. Many mice infected with a pathogenic strain of Cryptococcus neojormans and maintained, with elevated body temperatures, at 35 to 36°C, lived longer than all infected mice kept at 24 to 27°C.

2. These and previous in vitro studies suggest that a direct effect of temperature should be considered in explaining the degree of natural resistance of rabbits to cryptococcosis.

3. Elevated body temperatures might be useful in assisting treatment of human cryptococcosis.