Abstract
Summary
Thirteen female and 9 male subjects have been given a total of 67 intravenous infusions of from 100 to 400 mg of conjugated natural estrogens dissolved in 200 cc of normal saline. In the main, these infusions were well tolerated. Serum levels of estrogen as determined by bioassay varying from 17.6 to 48 μg were obtained and only negligible quantities of estrogen remained in the blood after 8 hours.
The feasibility of rapidly inducing a high serum estrogen level by intravenous infusion is demonstrated. The clinical usefulness of this form of estrogen therapy in carcinoma of the breast and prostate remains to be evaluated.
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