Abstract
Summary
Periods of 24, 48 and 72 hours of fasting constantly, though not always significantly, depress the blood-fibrinogen concentration in intact rats.
The blood-fibrinogen response to trauma is unaffected by fasting periods of 48 and 72 hours.
Simultaneous exposure to cold and fasting significantly reduces the fibrinogen rise induced by trauma.
Total adrenalectomy greatly decreases but does not abolish the fibrinogen response to injury. However, the blood-fibrinogen increase following an operation is prolonged in totally adrenalectomized as compared to partially adrenalectomized rats.
These observations suggest that the adrenals play an important role in fibrinogen metabolism.
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